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Viruses impact all levels of cellular biology and our lab studies these molecular interactions to understand the intricate interplay between a virus and its host cell. We characterise viral infections using cutting edge imaging and molecular tools in a variety of primary and cell-line based models. Our particular focus is understanding how viruses impact the homeostatic balance of cellular physiology and pathology.

Detecting SARS-CoV-2 by smFISH and Immunofluorescence

Our research focuses on understanding the complex interplay between the virus and the host cell in diseases that impact human health. Specifically, our research is centred around investigating the relationship between the hypoxic-inducible-factor (HIF) oxygen sensing pathway and viral replication. HIF-regulated pathways are often overlooked since most viral replication systems are cultured at atmospheric oxygen and our work has uncovered new intrinsic host pathways that regulate infection and are likely to impact a wide range of viruses.

Recently, we showed that human coronaviruses are sensitive to the host-hypoxic signalling and lead a program of research to study how this pathway regulates the replication of these viruses as well as other respiratory pathogens.











Our Team

Selected publications


Matthew Bottomley - CAMS Oxford Institute

Adan Pinto-Fernandez - CAMS Oxford Institute

Tammie Bishop - TDI Nuffield Department of Medicine

Related research themes