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8. Big Data and Computational Biology

To study the mechanisms of Chinese medicines which should facilitate improved clinical efficacy and broaden our views on the understanding and treatment of human diseases.

THEME LEADERS

Chen Wu

PRINCIPAL INVESTIGATORS

Groups within this theme

Our group focuses on how protein post-translational modification (PTM) enzymes modulate cell-cell communication in health and disease. PTMs diversify the biochemical and biophysical properties of proteins modulating trafficking, membrane diffusion, supramolecular organisation, stability, recycling, binding to cognate ligands and sorting into extracellular particles. Our mission is to discover the overarching hierarchy of enzymes modulating the intercellular networks of human immunity.

Cespedes-Donoso Group | Post-Translational Control of Human Intercellular Communication

Translational research of the pathogenesis and therapeutic approach to bacterial infection-derived autoimmune sequalae.

Chen Group | Lipid-mediated T cell immunity

The overarching goal of the Laboratory for Functional Immunology is to improve our understanding of cellular and molecular mechanisms underlying the regulation of germinal centre responses in vaccination, infection, and cancer, to dissect mechanistic targets that could be used to improve vaccines and therapeutic strategies.

IPP Group | Functional Immunology