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Sepsis patients could get the right treatment faster based on their genes

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Sepsis patients could be treated based on their immune system’s response to infection, not their symptoms. New research uncovers how different people respond to sepsis based on their genetic makeup, which could help identify who would benefit from certain treatments and lead to the development of targeted therapies.

Novel data method sheds light on hidden patterns of kidney inflammation

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Globally kidney disease is forecast to be the 5th leading cause of death by 2040, and in the UK more than 3 million people are living with the most severe stages of chronic kidney disease. Chronic kidney disease is often due to autoimmune damage to the filtration units of the kidney, known as the glomeruli, which can occur in lupus, a disease which disproportionally affects women and people of non-white ethnicities, groups often underrepresented in research. Treatment options are limited, can have life threatening side-effects and often don’t slow the disease, which can then progress to end stage, requiring dialysis or a kidney transplant.

Three CAMS Oxford Institute Principal Investigators elected to the Fellowship of the Academy of Medical Sciences

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Professor Teresa Lambe OBE, Professor Julian Knight & Professor Jane McKeating have been elected as Fellows of the Academy of Medical Sciences, one of the most prestigious awards in the field.

Nature Nanotechnology study introduces new and improved version of all-in-one coronavirus vaccine

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CAMS Oxford Institute researchers publish an improved version of a novel all-in-one vaccine against coronavirus threats in Nature Nanotechnology.

Ono Pharmaceutical Co collaborates with CAMS Oxford Institute & Centre for Medicines Discovery for translational research

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The Centre for Medicines Discovery (CMD) and CAMS Oxford Institute (COI) at NDM, has recently partnered with Ono Pharmaceutical Co (Ono) to validate and develop novel targets in a bid to discover innovative medicines.

NLRP3 Inflammasome “DUBbed” by UCH-L1, affecting IL-1β production in macrophages and microglia

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A Cell Reports study led by Prof. Benedikt Kessler provides an intricate time-resolved molecular map of different phases of NLRP3 inflammasome activation and unveils ubiquitin C-terminal hydrolase 1 (UCH-L1) as a modulator of NLRP3 inflammasome assembly and IL-1β production.

CAMS Oxford Institute Symposium held in Oxford

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The annual CAMS Oxford Institute Symposium was held on Monday 15th April 2024 in the Richard Doll Building on Old Road Campus for a full day of scientific talks, poster presentations & networking.

Novel pairing of integrins improves action of T cells on cancer cells to control tumour growth

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New research published in Nature Immunology showcases the collaborative efforts of CAMS Oxford Institute researchers to describe a novel pairing of integrins which could improve T cell control of cancer.

Ricardo Fernandes awarded a Cancer Research UK Immunology Project Award

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CAMS-Oxford Institute Principal Investigator, Ricardo Fernandes, has been awarded a competitive grant from Cancer Research UK to study anti-tumour T cell responses.

Assistant Professor Yunlong Cao visits CAMS Oxford Institute

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On 1st- 2nd of February 2024, Assistant Professor Yunlong Cao from Peking University, Beijing, China, visited the Chinese Academy of Medical Sciences Oxford Institute (COI), Nuffield Department of Medicine (NDM), University of Oxford.

Longitudinal study shows how immune responses to SARS-CoV-2 decline over time

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In a study led by CAMS Researchers, patients were tracked for two years post COVID-19 infection in a bid to understand how memory immune responses decline over time and give insight into vaccination & booster strategies.

2023 Round Up

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A note from our Directors on the success of 2023 for the CAMS Oxford Institute.

Super-Enhancer Components Work as a Team to Increase Gene Expression of Alpha-globin

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Researchers from Oxford University & New York University have revealed how super-enhancers work to increase gene expression of the α-globin gene.

Novel processing enzyme for ISG15 discovered

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Researchers from the CAMS Oxford Institute and NDM Target Discovery Unit, including Prof. Benedikt Kessler and Dr. Adán Pinto-Fernández, have collaborated with the team of Dr. Paul Geurink and Dr. Aysegul Sapmaz from Leiden University to investigate an important interferon-stimulated gene, ISG15.

Mapping proteins in brain tumours to help understand cancer

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A group of researchers led by Dr Roman Fischer at NDM’s Target Discovery Institute, Centre for Medicines Discovery (CMD) and CAMS Oxford Institute Principal Investigator has developed a method to study proteins in human tumours by creating detailed maps that show how much of each protein is present in different parts of the tissue.

Single cell spatial analysis provides new insight into immune-pathology in COVID-19 lungs

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A Nature Communications study led by Professor Ling-Pei Ho’s group provides new insights into how immune cells interact in the lungs of patients with severe COVID-19.

Cutting through the fat to understand how lipids influence immune responses

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An international team of scientists, including CAMS Oxford Institute group leaders Prof. Graham Ogg & Dr Yi-Ling Chen, have developed a method for simultaneously detecting thousands of lipid molecules that are displayed to T cells in the human immune system.

Christina Heroven awarded Early Career Fellowship by Wellcome Trust

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COI Postdoctoral scientist Dr Christina Heroven has been awarded a competitive Early Career Fellowship by the Wellcome Trust, providing funding for five years to support her career progression.

Beijing CDC Delegation Visits CAMS Oxford Institute

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Across Wednesday 20th and Thursday 21st September 2023, a delegation from the Beijing Center for Disease Prevention and Control (Beijing CDC) visited the Chinese Academy of Medical Sciences Oxford Institute (COI), NDM, University of Oxford.

Inaugural CAMS PUMC – Oxford Summer School in Beijing encourages the next generation of researchers to speak out

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CAMS PUMC – Oxford Summer School in Beijing exposes next generation of Chinese researchers to a more active and informal method of teaching.

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