SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Journal article

Dejnirattisai W. et al, (2022), Cell, 185, 467 - 484.e15

Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study.

Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers

An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Reduced neutralisation of SARS-CoV-2 omicron B.1.1.529 variant by post-immunisation serum.

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.

AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific Th1 response with a diverse TCR repertoire

Journal article

Swanson PA. et al, (2021), Science Translational Medicine

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Priority index: database of genetic targets in immune-mediated disease.

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells.

Immunodominance complexity: lessons yet to be learned from dominant T cell responses to SARS-COV-2

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

Antibody evasion by the P.1 strain of SARS-CoV-2

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2

Host genetics and infectious disease: new tools, insights and translational opportunities

IFITM3-specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans.

The antigenic anatomy of SARS-CoV-2 receptor binding domain

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

DUB esterase activity further decodes ubiquitin’s enigma

Journal article

Kessler BM., (2021), Proceedings of the National Academy of Sciences, 118, e2026389118 - e2026389118

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.

Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities

Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.

Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.

Malignancy and IFITM3: Friend or Foe?

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

Human cancer germline antigen-specific cytotoxic T cell—what can we learn from patient

Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019

A Novel Scoring System for Prediction of Disease Severity in COVID-19.

Defective Interferon Gamma Production by Tumor-Specific CD8+ T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter

Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans

A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer

Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses

IFITM3: How genetics influence influenza infection demographically

Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial.

Journal article

Stuart ASV. et al, (2022), Lancet (London, England), 399, 36 - 49

Why do breakthrough COVID-19 infections occur in the vaccinated?

HIF1α-mediated RelB/APOBEC3B downregulation allows Hepatitis B Virus persistence.

Promises and challenges of adoptive T-cell therapies for solid tumours

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine.

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

Immune Responses to a Single Dose of the AZD1222/Covishield Vaccine at 16 Weeks in Individuals in Sri Lanka.

Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.

Reactivation of a developmentally silenced embryonic globin gene.

Pleural Fluid Has Pro-Growth Biological Properties Which Enable Cancer Cell Proliferation

Journal article

Asciak R. et al, (2021), Frontiers in Oncology, 11

HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities.

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments

Ubiquitomics: An Overview and Future

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial (vol 396, pg 467, 2020)

Clinical and epidemiological features of COVID-19 family clusters in Beijing, China

Biological effect of tissue plasminogen activator (t-PA) and DNase intrapleural delivery in pleural infection patients

Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences

Journal article

Lee JY. et al, (2021)