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2. Viral Infection

Collaborative projects are currently investigating influenza and sepsis, for example, looking at how genetic variation affects the immune response to these infections and using this information to develop better vaccines and therapies. This theme will expand the current scope to include other important infections such as Zika and Dengue virus.

THEME LEADERS

PRINCIPAL INVESTIGATORS

Benedikt Kessler

Andrew McMichael

Groups within this theme

Our lab has an interest in studying how cellular Ubiquitylation and ISGylation influence cancer inflammation with the final aim of translating these findings into valid therapeutic targets. To study these pathways we use state-of-the-art MS-based omics techniques such as proteomics and lipidomics in combination with immunology and cellular biology functional assays.

Pinto-Fernández Group | Translational Ubiquitomics - Cancer Immunology

Exploring the translational impact of immune ageing and pharmacological immunosuppression upon peripheral immunity to viruses and malignancy

Bottomley Group | Immunity of Ageing

Our group focuses on how protein post-translational modification (PTM) enzymes modulate cell-cell communication in health and disease. PTMs diversify the biochemical and biophysical properties of proteins modulating trafficking, membrane diffusion, supramolecular organisation, stability, recycling, binding to cognate ligands and sorting into extracellular particles. Our mission is to discover the overarching hierarchy of enzymes modulating the intercellular networks of human immunity.

Cespedes-Donoso Group | Post-Translational Control of Human Intercellular Communication

Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.

Dong Group | T cell responses against Viruses & Cancer

• Dissecting and manipulating immune receptor signalling
• Discovery-led approaches to guide the engineering of novel proteins that potentiate robust immune responses against tumours and infection
• Developing methods to identify targets of immune recognition

Fernandes Group | Immune signalling in health & disease

Our research centers around the influenza neuraminidase protein as a promising target for therapeutic interventions, including antibodies, drugs, and vaccines.

Rijal Group | Antibodies and Vaccines targeting Influenza virus

Viruses impact all levels of cellular biology and our lab studies these molecular interactions to understand the intricate interplay between a virus and its host cell. We characterise viral infections using cutting edge imaging and molecular tools in a variety of primary and cell-line based models. Our particular focus is understanding how viruses impact the homeostatic balance of cellular physiology and pathology.

Wing Group | Molecular Virology