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2. Viral Infection

Collaborative projects are currently investigating influenza and sepsis, for example, looking at how genetic variation affects the immune response to these infections and using this information to develop better vaccines and therapies. This theme will expand the current scope to include other important infections such as Zika and Dengue virus.

THEME LEADERS

Julian Knight

Jianwei Wang

PRINCIPAL INVESTIGATORS

Xuetao Cao

Tao Dong

Wei He

Chenyu Jiang

Jiandong Jiang

Benedikt Kessler

Jane McKeating

Andrew McMichael

Graham Ogg

Zihe Rao

Gavin Screaton

Alison Simmons

Dave Stuart

Alain Townsend

Yonghong Zhang



Groups within this theme

Our lab has an interest in studying how cellular Ubiquitylation and ISGylation influence cancer immune evasion with the final aim of translating these findings into valid therapeutic targets. To study these pathways we use state-of-the-art MS-based omics techniques such as proteomics and lipidomics in combination with immunology and cellular biology functional assays.
Pinto-Fernández Group | Translational Ubiquitomics - Cancer Immunology
Exploring the translational impact of immune ageing and pharmacological immunosuppression upon peripheral immunity to viruses and malignancy
Bottomley Group | Immunity of Ageing
Our group focuses on understanding how protein post-translational modification (PTM) enzymes modulate cell-cell communication in health and disease. PTMs diversify the biochemical and biophysical properties of proteins modulating trafficking, membrane diffusion, supramolecular organisation, stability, recycling, binding to cognate ligands and sorting into extracellular particles. Our mission is to discover the overarching hierarchy of enzymes modulating the intercellular networks of human immunity.
Cespedes-Donoso Group | Post-Translational Control of Lymphocyte Communication
Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.
Dong Group | T cell responses against Viruses & Cancer
• Dissecting and manipulating immune receptor signalling • Discovery-led approaches to guide the engineering of novel proteins that potentiate robust immune responses against tumours and infection • Developing methods to identify targets of immune recognition
Fernandes Group | Immune signalling in health & disease
Our research focuses on the influenza virus neuraminidase protein as a promising target for both disease prevention and therapeutic strategies, including vaccines, drugs, and antibodies.
Rijal Group | Antibodies and Vaccines targeting Influenza virus
Our main research is to understand immune-responses, particularly antibody responses, against emerging pathogens, such as dengue virus, zika virus, HIV, Ebola virus, SARS and MERS and, the most recent, SARS-CoV2.
Screaton & Mongkolsapaya Group | Antibody Responses to emerging pathogens
Viruses impact all levels of cellular biology and our lab studies these molecular interactions to understand the intricate interplay between a virus and its host cell. We characterise viral infections using cutting edge imaging and molecular tools in a variety of primary and cell-line based models. Our particular focus is understanding how viruses impact the homeostatic balance of cellular physiology and pathology.
Wing Group | Molecular Virology
In this section