Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Dengue virus co-opts innate type 2 pathways to escape early control of viral replication.
Fonseka CL. et al, (2022), Communications biology, 5
HLA‐dependent variation in SARS‐CoV‐2 CD8
T cell cross‐reactivity with human coronaviruses
Buckley PR. et al, (2022), Immunology
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
Peng Y. et al, (2022), Nature Immunology, 23, 50 - 61
EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old.
Agache I. et al, (2022), Allergy, 77, 17 - 38
Phospholipase activity of Acyloxyacyl Hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Singh R. et al, (2021), European Journal of Immunology