Research groups
Peter Wing
PhD
Career Development Fellow
- Manager of the NDM Research Building Containment Level 3 Laboratory
Research Summary
My research focuses on understanding the complex interplay between the virus and the host cell in diseases that impact human health. Specifically, my research is centred around investigating the relationship between the hypoxic-inducible-factor (HIF) oxygen sensing pathway and viral replication. HIF-regulated pathways are often overlooked since most viral replication systems are cultured at atmospheric oxygen and our work has uncovered new intrinsic host pathways that regulate infection and are likely to impact a wide range of viruses.
Recently, I showed that human coronaviruses are sensitive to the host-hypoxic signalling and am leading a program of research to study the interplay of this pathway in the replication of these viruses as well as other respiratory pathogens.
Recent publications
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Oxygen-dependent histone lysine demethylase 4 restricts hepatitis B virus replication
Journal article
Harris JM. et al, (2024), Journal of Biological Chemistry, 300, 105724 - 105724
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Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression.
Journal article
Zhuang X. et al, (2024), iScience, 27
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The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.
Journal article
Tsukuda S. et al, (2024), PLoS pathogens, 20
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HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation
Journal article
Yang H. et al, (2023), Science Immunology, 8
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An enrichment protocol and analysis pipeline for long read sequencing of the hepatitis B virus transcriptome
Journal article
Ng E. et al, (2023), Journal of General Virology, 104