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1. Cancer Immunology & Immunotherapy

This theme builds on on-going collaborative projects that aim to understand how immune cells respond to cancer. The findings will be used to help identify new targets for cancer vaccine design and for immunotherapy in which T cells are recruited against tumour cells.

Theme Leaders

Principal investigators

Richard Cornall

Benedikt Kessler

Ricardo Fernandes

Groups within this theme

Our lab has an interest in studying how cellular Ubiquitylation and ISGylation influence cancer inflammation with the final aim of translating these findings into valid therapeutic targets. To study these pathways we use state-of-the-art MS-based omics techniques such as proteomics and lipidomics in combination with immunology and cellular biology functional assays.

Pinto-Fernández Group | Translational Ubiquitomics - Cancer Immunology

Exploring the translational impact of immune ageing and pharmacological immunosuppression upon peripheral immunity to viruses and malignancy

Bottomley Group | Immunity of Ageing

Our group focuses on understanding how protein post-translational modification (PTM) enzymes modulate cell-cell communication in health and disease. PTMs diversify the biochemical and biophysical properties of proteins modulating trafficking, membrane diffusion, supramolecular organisation, stability, recycling, binding to cognate ligands and sorting into extracellular particles. Our mission is to discover the overarching hierarchy of enzymes modulating the intercellular networks of human immunity.

Cespedes-Donoso Group | Post-Translational Control of Lymphocyte Communication

Translational research of the pathogenesis and therapeutic approach to bacterial infection-derived autoimmune sequalae.

Chen Group | Lipid-mediated T cell immunity

Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.

Dong Group | T cell responses against Viruses & Cancer

The overarching goal of the Laboratory for Functional Immunology is to improve our understanding of cellular and molecular mechanisms underlying the regulation of germinal centre responses in vaccination, infection, and cancer, to dissect mechanistic targets that could be used to improve vaccines and therapeutic strategies.

IPP Group | Functional Immunology

Laboratory of Translational Pleural Research

Kanellakis Group | Translational Pleural Research

• Dissecting and manipulating immune receptor signalling
• Discovery-led approaches to guide the engineering of novel proteins that potentiate robust immune responses against tumours and infection
• Developing methods to identify targets of immune recognition

Fernandes Group | Immune signalling in health & disease