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Professor Xuetao Cao

Xuetao CaoProfessor of Immunology CAMS/PUMC

Professor Xuetao Cao is the current President of Nankai University, China and the former President of the Chinese Academy of Medical Sciences and Peking Union Medical College until February 2018. Professor Cao was elected to the Chinese Academy of Engineering in 2005, German Academy of Sciences in 2013 and French Academy of Medicine in 2014. He was President of Chinese Society for Immunology for 8 years (2006.10-2014.10). He is currently the Secretary General of Chinese Society for Immunology (2014.10- ), President of Federation of Immunological Societies in Asia and Oceania FIMSA (2012.5- 2015.6) and President of Global Alliance for Chronic Diseases GACD (2013.12-2015.12).

Professor Xuetao Cao’s major interests are innate response and immune regulation, immunobiology of APCs (dendritic cells, macrophages), cancer immunotherapy. He has made important contributions to the understanding of signaling pathways in innate immunity and inflammation, identification of immune cell subsets and new immune molecules in immune response and cancer, all of his work was completed in China.

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Professor Wei He

Wei HeProfessor, Institute of Basic Medical Sciences, CAMS/PUMC

In Aug. 1994, Professor He returned to China and joined the laboratory of Professor Denain Ba in Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC). One year later, he obtained a full Professorship in CAMS & PUMC, and developed his interest in γδT cells, going on to obtain a dozen national and international grants leading his students to embark on the study of γδT cells, focusing on a relationship with tumour-immunology.

Wei He is also a leader in the Chinese Society for Immunology (CSI) (Secretary General 2001-present, Vice-President 2010-present), and represents CSI at the International Union of Immunological Societies (IUIS) as the Member, Education Committee of IUIS (2005-present).

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Professor Zihe Rao

Zihe RaoProfessor of Structural Biology

Professor Zihe Rao graduated from the University of Science and Technology of China (USTC) in 1977, and got his master degree from the Institute of Biophysics, Chinese Academy of Sciences (CAS) in 1982. In 1989, Professor Rao received his doctorate from Melbourne University and then joined Prof. Dave Stuart’s group in Oxford University, where he worked until 1996. He is now a professor and head of the Laboratory for Structural Biology at Tsinghua University.

Professor Rao's interests are Structural Virology; Structural Biology; Mechanical signaling in tumor and immunology.

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Professor Tao Cheng

Tao ChengDirector and Professor, Institute of Haematology and Blood Diseases Hospital, CAMS/PUMC

Prof. Cheng‘s laboratory primarily focuses on both genetic and epigenetic mechanisms in hematopoietic stem and progenitor cells, with each project guided by approaches intended to elucidate basic principles and develop practical strategies. Leukemia and bone marrow failure are the main diseases against which research advances in the laboratory are achieved. Through broadly collaborative approaches, Prof. Cheng is also committed to training haematologists and stem cell biologists, and to building strong haematology and stem cell research programs that will ultimately benefit the patients.

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Professor Bo Huang

Bo HuangVice Director of Institute of Basic Medical Sciences, CAMS/PUMC

Chinese Academy of Medical SciencesProfessor Bo Huang is the Vice-Chairman of Department of Immunology, Chinese Academy of Medical Sciences (CAMS). He received his PhD in biochemistry and molecular biology from Tongji Medical College, Huazhong University of Science and Technology. He finished his postdoctoral training in the Karolinska Institutet in Sweden, University of Calgary in Canada, and Mount Sinai School of Medicine in United States. He is currently a Professor in the Department of Immunology, Chinese Academy of Medical Sciences (CAMS).

Professor Bo's major interests are Tumour immunology; Microparticles in tumour and immunology; Metabolism in tumour and immunology;Mechanical signalling in tumour and immunology.

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Professor Chenyu Jiang

Chenyu JiangProfessor and Executive Vice Dean of School of Basic Medical Sciences

Professor Jiang's research is to elucidate molecular pathogenesis of Acute Respiratory Distress Syndrome induced by RNA viruses such as SARS-CoV, Avian and Swine Influenza, and Ebola. Her group has also studied molecular mechanism of lung fibrosis, Psychiatry and Cancer. She has proposed a number of repurposing drugs after elucidation of disease molecular targets. She published extensively in peer-reviewed journals including Nature, Nature Medicine, Molecular Psychiatry, Cell Research, and Nature Communications.

She is also an inventor of a number of international patents. Some of the patents are exclusively licensed to a top 5 international pharmaceutical companies. She received numerous honors including “Cheung Kong” Scholar, the young woman scientist of China, and national outstanding young award fund. Professor Jiang's main interests are Medical Biochemistry and Molecular Biology and Respiratory Disease.

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Professor Jiandong Jiang

Jiandong JiangDirector of Institute of Materia Medica

Dr. Jiang obtained his M.D. degree in the Fudan University Shanghai School of Medicine (1988). He then spent 18 years in the Department of Medicine at the Mount Sinai Hospital. Dr. Jiang came back to China in 1999 and worked as the director of the Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences (CAMS) / Peking Union Medical College (PUMC) from 1999 to 2010. Dr. Jiang is currently the president of the Institutes of Pharmaceutical Sciences as well as director of the Institute of Materia Medica, CAMS / PUMC. In addition, he serves as the Chair of Department of Pharmacology in PUMC, and Editor-in-Chief for the Journal of Acta Pharmaceutica Sinica. Dr. Jiang’s research focuses on the drug R&D covers infectious diseases, cancer and metabolic disorders. Dr. Jiang holds 14 approved patents and has published over 160 articles in journals like Nature, Nature Medicine, Cancer Cell, Hepatology, PNAS et al. Two accomplishments of innovative drug research have been translated into clinical use, with one for the treatment of drug-resistant hepatitis B and one for treating metabolic syndromes. He has received two National Awards in China for his contribution in drug discovery.

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Professor De-pei Liu

Depei LiuDirector of National Laboratory of Medical Molecular Biology, CAMS & PUMC

Dr. De-Pei Liu graduated with a Ph.D. from CAMS & PUMC in 1986. He completed his Postdoctoral training in University of California, San Francisco (UCSF). Dr. Liu is currently a professor and director of State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS) & Peking PUMC. He is also serving as a member of Chinese Academy of Engineering (CAE), member of National Academy of Medicine (NAM) of the National Academies, USA and member of Third World Academy of Sciences (TWAS), Dr. Liu’s research expertise is molecular mechanisms of gene regulation, gene therapy and cardiovascular disease.

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PROFESSOR Hong SHang

100.jpegDirector of the Key Laboratory of AIDS Immunology of National Health Commission of China, the Vice President of China Medical University (CMU) and the president of the First Affiliated Hospital of CMU

Professor Hong Shang received her PhD from Yamanashi Medical University, Japan. Academic contributions have been made in the fields of HIV epidemiology, immunology, virology, and treatment by her group. Shang was the first to describe the epidemic features of HIV among MSM population in China, and proposed a comprehensive prevention and treatment approach. She also discovered novel recombinant viruses and co-identified an intracellular molecule, cofilin, in blood CD4 T cells of HIV patients, as the first molecular marker to quantify HIV-mediated immune dysfunction in blood CD4 T cells. She has also discovered a new HIV-restriction factor, TRABD2A, and described how resting CD4 T cells restrict HIV-1 virion release. Her studies have led to new therapeutic models for a functional cure of HIV infection. Shang discovered biomarkers (eg. microRNAs) predicting HIV rapid disease progression in the early stage of HIV infection, opening up a new approach to the diagnosis and prognosis of HIV-1 infections in clinical laboratories. Shang assessed the effect of hepatitis coinfection on clinical outcomes and adverse effect of antiretroviral therapy, strengthening the recommendation to systematically test all HIV-positive patients for HBV, HCV, and HDV, to expand HBV vaccination, and the access to treatment for viral hepatitis. Shang has published 153 research articles as the first author and the correspondence author in Nature, Nat Immunol, Science Advances, Lancet Infect Dis and etc. Five of her research findings have been authorized with invention patents.

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PROFESSOR CHEN WANG

ChenWang.png

Professor of respiratory diseases, President of the Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC).

Professor Wang has long been engaged in clinical practice, teachings and research on respiratory problems such as pulmonary embolism, pulmonary hypertension, respiratory failure, pulmonary heart disease, chronic obstructive pulmonary diseases (COPD, Chronic Bronchitis Emphysema), new respiratory infectious diseases and tobacco epidemiology.

 

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Professor Jianwei Wang

Jianwei WangDirector of Scientific Research Office CAMS/PUMC, Deputy Director (CAMS) CAMS Oxford Institute

Professor Jianwei Wang has been the director and associate professor (2005-2008)/full professor (2008-) of Christophe Merieux Laboratory, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC) since 2005 after he worked in China CDC for 8 years. He was the board member of national R&D high-tech project (863 project, 2011-2015). He also serves as the board member of National Major Project of Prevention and Treatment of AIDS, Hepatitis and Other Major Infectious Diseases in China. He is the recipient of National Fund of Distinguished Young Scientist (2012) and Changjiang Scholarship Professor (2014). He is the member of editorial board of many science journals and standing members of academic societies. He has authored or co-authored more than 100 original papers in international peer-reviewed journals, including 80 corresponding author papers. His main interests are Immunology of respiratory virus infection; virus-host interaction; innate immunity.

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Professor Ruozheng Wang

Ruozheng WangProfessor of radiation oncology, Consultant in Radiation Therapy, Director of CAMS key laboratory of Radiation Cancer Immunology

Professor Wang graduated from Xinjiang Medical University with BM degree in 1986, PHD degree in 2011 and completed postdoc training in Tianjin Medical University in 2015. She worked as registrar and consultant in Affiliated Tumour Hospital since 1991. During this period, she has visited MRC Human Immunology Unit (HIU) in University of Oxford and Nebraska Medical Center in US for futher training in immunology and radiation oncology.  Her main research interst is  to  understand how T cells, especially cytotoxic T cells, are involved in the initiation and progression of various type of cancer, such as nasopharyngeal cancer and cervical cancer. We would also like to discover novel targets of immune therapy which is important in precision medicine.

Her research projects are mainly funded by National Natural Science Foundation of China and Minister of Science and Technology. She has established nation-wide collaboration as well as international collaboration with Professor Tao Dong in University of Oxford. By far, she published 16 SCI papers. Thirty-seven postdoctoral researchers, PhD students and master candidates have worked or supervised by her. From 2015-2017 her group won three major awards from the Scientific and Technological Progress Prize in Xinjiang Uygur Autonomous Region. 

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Professor Chen Wu

Chen WuProfessor, National Cancer Center/Cancer Hospital Deputy Director

Professor Wu's main research aims are to further analyzing genomic data of gastroenterology cancers and to characterize the functions and molecular mechanisms of identified genes and their variants in these cancers

She has been focusing on cancer genetics and genomics. His group conducted several genome-wide association studies of esophageal squamous-cell carcinoma (ESCC), pancreatic cancer et al in Chinese populations and identified several novel loci or variants associated with risk of the development of these cancers. They have not only continued but also expanded the research into two aspects: one is to further analyze genomic data of esophageal and pancreatic cancer and the other is to characterize the functions and molecular mechanisms of identified genes and their variants in these cancers.

Current work is focusing on functional genomics screening of susceptible or driver genes and elucidation of the biological mechanisms of these genetic variations in ESCC.

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Professor Xuan Zhang

Xuan ZhangDirector of the Department of Research PUMC Hospital

Professor Xuan Zhang is Professor and Director of the Department of Research, Peking Union Medical College (PUMC) Hospital and Director of the Clinical Immunology Centre, Chinese Academy of Medical Science.

His speciality and research field of interest is Rheumatology and Clinical Immunology. He has engaged in clinical diagnosis, treatment, and research of pathogenesis of the Rheumatism immunity disease, the emphasis is the systemic lupus erythematosus, the rheumatoid arthritis and the immune interstitial pneumonia.

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Professor Xue Zhang

Xue ZhangProfessor and Chair of Medical Genetics, Vice President CAMS/PUMC

Prof. Zhang’s research focuses on the molecular basis of rare Mendelian disorders. He has discovered the disease genes underlying several monogenic disorders, including familial acne inversa, Marie Unna hereditary hypotrichosis, familial idiopathic basal ganglia calcification and syndactyly type V, and identified the pathogenic genomic rearrangements for congenital generalized hypertrichosis terminalis, X-linked congenital hypertrichosis syndrome and syndactyly type IV.

These findings have been published in high profile journals including Science, Nature Genetics and American Journal of Human Genetics.

Prof. Zhang has been on the editorial board of several international journals, including American Journal of Human Genetics, Annual Review of Genomics and Human Genetics, and Journal of Investigative Dermatology.

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Professor Yonghong Zhang

Yonghong ZhangDirector of Research Centre for Biomedical Resources, Director of Scientific Research Office, Beijing Youan Hospital, Capital Medical University

Professor. Yonghong Zhang received his D.Phil from Oxford University. He is currently a senior clinician in Beijing Youan Hospital and Associate Professor at Capital Medical University, Beijing.

Yonghong’s major interest is in anti-viral immunity and genetic association in virus infections such as influenza, HIV, HCV and HIV/HCV co-infection. Yonghong’s current work is focusing on IFITM3 genetic variant in association with severe influenza in China. He also showed evidence that the CTL driving pressure has a major effect on inter host HIV-1 viral diversity and probably represents a key element of viral control. In addition, Dr Zhang identified the immune mechanisms of HLA-B51-associated protection in HIV infection. As first author, he has published seven original papers in SCI-cited journals including Nature Communication, Journal of Immunology, Blood, Am J Respir Crit Care Med.

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Professor Zhendong Zhao

Zhendong ZhaoDirector of Division of Science and Technology, Institute of Pathogen Biology, CAMS/PUMC

The ongoing research work in my group focuses on the innate immune evasion mechanisms induced by different pathogens, such as EV71, HCV and MERS-CoV etc. and the impact on the host cell protein quality control system, including both autophagy and ERAD pathways, upon the viral infection, the cross talk between pathogen initiated innate signaling pathway and autophagy as well. In addition, my group also works on applying forward genetic approach (Validation-based insertional mutagenesis) to identify host factors that affect virus replication and reverse vaccinology strategy to screen potential mycobacteria antigens or adjuvants recognized by γδT cells. Finished work has been published on PloS Pathog, Autophagy etc.

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