Professor of Immunology
Our aim is to understand how the immune system is formed and regulated and the causes of autoimmunity, particularly the systemic autoimmune diseases, and the development and selection of B cells. Adverse immunological reactions to self and foreign antigens that lead to autoimmune or inflammatory disease place a major economic and social burden on world health and individual quality of life. We are also interested in how people differ in their inherited susceptibility to these diseases and why these differences are sustained in human populations by natural selection. Advances in this area will have a large and impact on the management of human disease.
Our strategy involves research programmes in basic biology and in clinical medicine. In the first, we use transgenic models to investigate how lymphocytes function in health and in human disease and how our genes encode susceptibility to autoimmunity and immunodeficiency. In the second, which is a collaboration with Professor Simon Davis, we are developing ways to change the function of lymphocytes, turning them on in cancer and off during inflammation or autoimmunity.
Partial retinal photoreceptor loss in a transgenic mouse model associated with reduced levels of interphotoreceptor retinol binding protein (IRBP, RBP3).
Liu Y-H. et al, (2018), Experimental eye research
Capturing resting T cells: the perils of PLL.
Santos AM. et al, (2018), Nature immunology
B1a B cells require autophagy for metabolic homeostasis and self-renewal
Clarke AJ. et al, (2018), Journal of Experimental Medicine
Immune Checkpoints as Therapeutic Targets in Autoimmunity.
Paluch C. et al, (2018), Front Immunol, 9
NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.
Schwerd T. et al, (2017), Mucosal immunology