Career Development Fellow
My research has been focussed on the innate lymphocyte mechanisms under inflammatory conditions, furthering the understanding of the roles of commensal and pathogen responses in tissue homeostasis and microbial defence at the cellular and molecular level. I have specific interests in the involvement of lipid-reactive T cells. With high dimensional transcriptomics, T cell clonality analysis, and TCR editing approaches, the main goal of my studies is to progress translationally towards the evaluation of promising new therapeutic targets and the discovery of new lipid candidates for immune intervention.
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation.
Chen Y-L. et al, (2023), Science immunology, 8
CD1a promotes systemic manifestations of skin inflammation.
Hardman CS. et al, (2022), Nature communications, 13
Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Monnot GC. et al, (2022), Nature immunology
Dengue virus co-opts innate type 2 pathways to escape early control of viral replication.
Fonseka CL. et al, (2022), Communications biology, 5
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Ahern DJ. et al, (2022), Cell, 185, 916 - 938.e58