Research groups
Colleges
Yi-Ling Chen
DPhil
Career Development Fellow
My research has been focussed on the innate lymphocyte mechanisms under inflammatory conditions, furthering the understanding of the roles of commensal and pathogen responses in tissue homeostasis and microbial defence at the cellular and molecular level. I have specific interests in the involvement of lipid-reactive T cells. With high dimensional transcriptomics, T cell clonality analysis, and TCR editing approaches, the main goal of my studies is to progress translationally towards the evaluation of promising new therapeutic targets and the discovery of new lipid candidates for immune intervention.
Collaborators
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Graham Ogg
Professor of Dermatology
Recent publications
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Hamid MHBA. et al, (2024), Nature Immunology, 25, 834 - 846
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A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells.
Sharma S. et al, (2024), Life Sci Alliance, 7
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CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms.
Huang S. et al, (2023), Cell, 186, 4583 - 4596.e13
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Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation.
Chen Y-L. et al, (2023), Science immunology, 8
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CD1a promotes systemic manifestations of skin inflammation.
Hardman CS. et al, (2022), Nature communications, 13