Colleges
Yi-Ling Chen
DPhil
Career Development Fellow
My research has been focussed on the innate lymphocyte mechanisms under inflammatory conditions, furthering the understanding of the roles of commensal and pathogen responses in tissue homeostasis and microbial defence at the cellular and molecular level. I have specific interests in the involvement of lipid-reactive T cells. With high dimensional transcriptomics, T cell clonality analysis, and TCR editing approaches, the main goal of my studies is to progress translationally towards the evaluation of promising new therapeutic targets and the discovery of new lipid candidates for immune intervention.
Collaborators
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Graham Ogg
Professor of Dermatology
Recent publications
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CD1a promotes systemic manifestations of skin inflammation.
Journal article
Hardman CS. et al, (2022), Nature communications, 13
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Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Journal article
Monnot GC. et al, (2022), Nature immunology
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Dengue virus co-opts innate type 2 pathways to escape early control of viral replication.
Journal article
Fonseka CL. et al, (2022), Communications biology, 5
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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Journal article
Ahern DJ. et al, (2022), Cell, 185, 916 - 938.e58
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Phospholipase activity of acyloxyacyl hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Journal article
Singh R. et al, (2022), European Journal of Immunology, 52, 511 - 524