Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
HLA‐dependent variation in SARS‐CoV‐2 CD8
T cell cross‐reactivity with human coronaviruses
Buckley PR. et al, (2022), Immunology
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
Peng Y. et al, (2022), Nature Immunology, 23, 50 - 61
Phospholipase activity of Acyloxyacyl Hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Singh R. et al, (2021), European Journal of Immunology
Surveillance of SARS-CoV-2 variants of concern by identification of single nucleotide polymorphisms in the spike protein by a multiplex real-time PCR.
Gomes L. et al, (2021), Journal of virological methods, 300
British Association of Dermatologists guidelines for the management of people with chronic urticaria 2021.
Sabroe RA. et al, (2021), The British journal of dermatology