Contact information
Research groups
Websites
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MRC Human Immunology Unit
Research Unit
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MRC Weatherall Institute of Molecular Medicine
Research Institute
Graham Ogg
Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Recent publications
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Dengue virus co-opts innate type 2 pathways to escape early control of viral replication.
Journal article
Fonseka CL. et al, (2022), Communications biology, 5
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HLA‐dependent variation in SARS‐CoV‐2 CD8
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T cell cross‐reactivity with human coronaviruses
Journal article
Buckley PR. et al, (2022), Immunology
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An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
Journal article
Peng Y. et al, (2022), Nature Immunology, 23, 50 - 61
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EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old.
Journal article
Agache I. et al, (2022), Allergy, 77, 17 - 38
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Phospholipase activity of Acyloxyacyl Hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Journal article
Singh R. et al, (2021), European Journal of Immunology