Postdoctoral research scientist and Bioinformatician
Contact information
Research groups
Elie Antoun
Senior Bioinformatician
Post-doctoral research scientist and BIoinformatician
My research focus in on the use of multimodal next generation sequencing technologies (e.g. RNAseq, ATACseq, Proteomics) to understand the complexities involved in T cell function and regulation during viral infection and in cancer settings. Currently, I am looking into:
- The function and regulation of cytotoxic CD4+ T cells, and epigenetics mechanisms that may regulate T cells function.
- Using TCR repertoire sequencing and machine learning algorithms to understand TCR clonality and specificity.
As both a wet lab scientist and a bioinformatician, I can efficiently link the biology with the bioinformatic analysis to gain a deeper understanding into T cell function and heterogeneity
Recent publications
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Pleural fluid proteomics from patients with pleural infection shows signatures of diverse neutrophilic responses: The Oxford Pleural Infection Endotyping Study (TORPIDS-2)
Journal article
Kanellakis NI. et al, (2025), European Respiratory Journal, 66, 2500010 - 2500010
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Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis
Journal article
Pinho MP. et al, (2025), Cell Reports Medicine, 102252 - 102252
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Localised signalling networks co-opt TGF-β2 to promote an immuno-exclusive mesenchymal niche within human squamous cell carcinoma
Preprint
Bottomley MJ. et al, (2025)
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T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination
Journal article
Chen J-L. et al, (2025), Nature Communications, 16
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Journal article
Hamid MHBA. et al, (2024), Nature Immunology, 25, 834 - 846