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A new research discovered circulating antigen-specific CD103+CD8+ T cells can self-regulate their CD103 expression via production of active TGFβ1 and have better TCR signalling and effector function compared to CD103- populations.

However, this population undergoes increased death with prolonged exposure to tumour cells, the results from Tao Dong’s group are published in Cancer Immunology Research Online First Publication.

Hamid et al, Cancer Immunol Res 2019

Self-maintaining CD103+ cancer-specific T cells