Publications for all Oxford Principal Investigators within the CAMS Oxford Institute are included here, please use the search functions for publications related to specific Principal Investigators.
Active regulatory elements recruit cohesin to establish cell specific chromatin domains.
Georgiades E. et al, (2025), Scientific reports, 15
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis
Preston AE. et al, (2025), Nature Communications, 16
Author Correction: The α-globin super-enhancer acts in an orientation-dependent manner.
Kassouf MT. et al, (2025), Nat Commun, 16
Identification of new candidate drugs in myelodysplastic syndromes with splicing factor mutations by transcriptional profiling and connectivity map analysis
Sun T. et al, (2025), British Journal of Haematology
The α-globin super-enhancer acts in an orientation-dependent manner
Kassouf MT. et al, (2025), Nature Communications, 16
Loss-of-Function Variants in SUPT5H as Modifying Factors in Beta-Thalassemia.
Harteveld CL. et al, (2024), International journal of molecular sciences, 25
The characteristics of CTCF binding sequences contribute to enhancer blocking activity.
Tsang FH. et al, (2024), Nucleic acids research
Developing a pill to treat sickle cell disease.
Higgs D. and Kassouf M., (2024), Science (New York, N.Y.), 385, 27 - 28
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes.
Xiang G. et al, (2024), Genome research
Beginnings: The molecular pathology of hemoglobin
Higgs D. and Badat M., (2024), Molecular Hematology, 1 - 16
Haemoglobin Bart's Hydrops Fetalis: Charting the Past and Envisioning the Future.
Amid A. et al, (2024), Blood
Super-enhancers include classical enhancers and facilitators to fully activate gene expression.
Blayney JW. et al, (2023), Cell
Active regulatory elements recruit cohesin to establish cell-specific chromatin domains
Georgiades E. et al, (2023)
Ancient genomic linkage couples metabolism with erythroid development.
Preston AE. et al, (2023), bioRxiv
The characteristics of CTCF binding sequences contribute to enhancer blocking activity
Tsang FH. et al, (2023)
RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.
Martell DJ. et al, (2023), Developmental cell
P104: BASE EDITING REPAIRS THE HBE MUTATION RESTORING THE PRODUCTION OF NORMAL GLOBIN CHAINS IN SEVERE HBE/β-THALASSEMIA PATIENT HEMATOPOIETIC STEM AND ERYTHROID CELLS
Badat M. et al, (2022), HemaSphere, 6, 19 - 20
An Ancient Transcriptional Hub Couples Developmentally Regulated Gene Expression with Metabolism during Erythropoiesis
Preston AE. et al, (2022), BLOOD, 140