Publications for all Oxford Principal Investigators within the CAMS Oxford Institute are included here, please use the search functions for publications related to specific Principal Investigators.
USP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10
Mukhopadhyay R. et al, (2024)
Deubiquitinases in muscle physiology and disorders
Olie CS. et al, (2024), Biochemical Society Transactions, 52, 1085 - 1098
Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1
Imhoff RD. et al, (2024), Journal of Medicinal Chemistry, 67, 4496 - 4524
Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6
Dietz L. et al, (2023), Science, 379, 1112 - 1117
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
O’Brien DP. et al, (2022)
Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics
Pinto-Fernández A. et al, (2019), Frontiers in Chemistry, 7
Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting
Olie CS. et al, (2019), iScience, 12, 318 - 332
Human Platelet Protein Ubiquitylation and Changes following GPVI Activation
Unsworth A. et al, (2019), Thrombosis and Haemostasis, 119, 104 - 116
A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN
Weber A. et al, (2017), Cell Chemical Biology, 24, 1299 - 1313.e7
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Turnbull AP. et al, (2017), Nature, 550, 481 - 486
DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets
Pinto-Fernandez A. and Kessler BM., (2016), Frontiers in Genetics, 7