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A 3.6-kb region of the Shope fibroma virus (SFV) BamHI D fragment located in the central region of the viral genome was sequenced. Three open reading frames (ORFs) were identified, D3R, D4L, and D5R. Each of these ORFs have a counterpart organized identically within the HindIII fragment D of the vaccinia virus genome (D1R, D2L, and D3R). Homology scores and assays of viral cores indicate that SFV D3R encodes the large subunit of the SFV mRNA capping enzyme.


Journal article



Publication Date





773 - 777


Amino Acid Sequence, Base Sequence, DNA, Viral, Fibroma Virus, Rabbit, Genes, Viral, Methyltransferases, Molecular Sequence Data, Multienzyme Complexes, Nucleotidyltransferases, Open Reading Frames, Phosphoric Monoester Hydrolases, RNA Caps, Restriction Mapping, Sequence Alignment, Sequence Homology, Nucleic Acid, Viral Proteins