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Direct visualization and quantification of antigen-specific T cells using major histocompatibility complex (MHC)/peptide tetramer technology offers a powerful means to study specific T cell populations of interest. In combination with functional assays, this technology has already provided many new insights into several long-standing immunological concepts in basic science as well as clinical settings.

Type

Journal article

Journal

J Immunol Methods

Publication Date

01/10/2002

Volume

268

Pages

21 - 28

Keywords

Apoptosis, Autoimmunity, Graft Rejection, Histocompatibility Antigens Class I, Humans, Immunotherapy, In Vitro Techniques, Lymphocyte Activation, Models, Immunological, Neoplasms, Protein Structure, Quaternary, Signal Transduction, T-Lymphocytes, T-Lymphocytes, Cytotoxic