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During the past year, the database of ligand-receptor complexes has essentially doubled. These new results have immeasurably extended and expanded our view of cell surface receptor structure and function. The flood of data has revealed new models for receptor cross-linking, demonstrating the potential stringency of the extracellular requirements for the initiation of intracellular signalling and highlighting unexpected interactions suggestive of higher order clustering.


Journal article


Curr Opin Struct Biol

Publication Date





213 - 219


Animals, Apoptosis, Binding Sites, Cell Adhesion Molecules, Cytokines, Growth Substances, Humans, Iron, Ligands, Models, Molecular, Protein Binding, Receptors, Cell Surface, Receptors, Cytokine, Receptors, Growth Factor, Receptors, Immunologic, Receptors, Virus, Signal Transduction, Templates, Genetic