Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL
Iacovelli S., Hug E., Bennardo S., Duehren-von Minden M., Gobessi S., Rinaldi A., Suljagic M., Bilbao D., Bolasco G., Eckl-Dorna J., Niederberger V., Autore F., Sica S., Laurenti L., Wang H., Cornall RJ., Clarke SH., Croce CM., Bertoni F., Jumaa H., Efremov DG.
<jats:title>Key Points</jats:title> <jats:p>Cell autonomous BCR interactions and interactions with low-affinity autoantigens drive leukemia development in an in vivo model of CLL. BCR signals induced by binding to external antigen can increase the aggressiveness of CLL.</jats:p>