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Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all forms of villous trophoblast. The extra-villous trophoblast which reacted with antibodies to monomorphic class 1 MHC antigens consistently failed to bind HLA-A or HLA-B antibodies specific for the foetal phenotype. This suggests, but does not prove, that the MHC antigen expression of trophoblast may be restricted to HLA-C or some other undefined class 1 antigen.


Journal article



Publication Date





457 - 468


Chorion, Trophoblasts, Placenta, Humans, beta 2-Microglobulin, HLA-A Antigens, HLA-B Antigens, HLA-C Antigens, HLA Antigens, Epitopes, Immunoenzyme Techniques, Antibody Specificity, Major Histocompatibility Complex, Pregnancy, Female