Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection
Allen TM., Jing P., Calore B., Horton H., O'Connor DH., Hanke T., Piekarczyk M., Ruddersdorf R., Mothé BR., Emerson C., Wilson N., Lifson JD., Belyakov IM., Berzofsky JA., Wang C., Allison DB., Montefiori DC., Desrosiers RC., Wolinsky S., Kunstman KJ., Altman JD., Sette A., McMichael AJ., Watkins DI.
<jats:title>ABSTRACT</jats:title> <jats:p>Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.</jats:p>