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<jats:title>ABSTRACT</jats:title> <jats:p>Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct “central memory” CD62L<jats:sup>+</jats:sup> phenotype.</jats:p>

Original publication

DOI

10.1128/jvi.78.13.7284-7287.2004

Type

Journal article

Journal

Journal of Virology

Publisher

American Society for Microbiology

Publication Date

01/07/2004

Volume

78

Pages

7284 - 7287