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The EC 'Structural Proteomics In Europe' contract is aimed specifically at the atomic resolution structure determination of human protein targets closely linked to health, with a focus on cancer (kinesins, kinases, proteins from the ubiquitin pathway), neurological development and neurodegenerative diseases and immune recognition. Despite the challenging nature of the analysis of such targets, approximately 170 structures have been determined to date. Here, the impact of high-throughput technologies, such as parallel expression of multiple constructs, the use of standardized refolding protocols and optimized crystallization screens or the use of mass spectrometry to assist sample preparation, on the structural biology of mammalian protein targets is illustrated through selected examples.

Original publication




Journal article


Acta Crystallogr D Biol Crystallogr

Publication Date





1208 - 1217


Animals, Eukaryotic Cells, Gene Expression, Genetic Research, Humans, Immune System, Mass Spectrometry, Neoplasms, Nervous System Diseases, Proteins, Proteomics