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The basic structures of MHC class I and class II molecules are now well established. Over the past twelve months structural data on MHC class I molecules have provided details of the peptide binding groove for a number of alleles and have elaborated the mechanisms that allow binding of a range of peptides. Recent MHC class II structures have illustrated the mode of peptide binding both in mature complexes and in the MHC class II complex with a fragment of invariant chain (CLIP) during maturation.


Journal article


Curr Opin Immunol

Publication Date





75 - 79


Animals, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Humans, Protein Conformation, Structure-Activity Relationship