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Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their receptors.


Journal article


Curr Biol

Publication Date





500 - 507


Amino Acid Sequence, Animals, Fibroblast Growth Factors, Humans, Ligands, Molecular Sequence Data, Mutation, Protein Conformation, Receptors, Fibroblast Growth Factor