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BackgroundManagement and outcomes in women with placenta accreta spectrum grade 3 are rarely reported from population-based studies. The objective of this study is to describe profiles, management, and outcomes, of women with placenta accreta spectrum (PAS) grade 3 from three multiperiod studies.MethodsThis analysis used data from three multiperiod population-based cohort studies from the United Kingdom (UK) (May 2010-April 2011), France (November 2013-October 2015), and Italy (September 2014-August 2016) to compare the management and outcomes of women with grade 3 PAS. The main outcome measures were postpartum hemorrhage (PPH) ≥ 3000 mL, blood transfusion ≥ 4 units, and other severe maternal complications (death, damage to bowel or urinary tract).ResultsThis study included 39 women with PAS grade 3 in the UK, 51 in France, and 34 in Italy, a total of 124 women. PAS was suspected before birth in 59% of the UK cases, 88% in France, and 82% in Italy (P ConclusionMaternal outcomes in women with grade 3 PAS varied between the three periods and countries, alongside the evolution in prenatal screening and peri-operative management.Trial registrationFor the UK: reference number: RP-PG-0608-10038. For France: reference number: AOR12156. For Italy: reference number: Port. PRE-839/13.

Original publication

DOI

10.1186/s12884-025-07271-2

Type

Journal

BMC pregnancy and childbirth

Publication Date

04/2025

Volume

25

Addresses

Université Paris Cité, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS) U 1153, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, 53 avenue de l'observatoire, Paris, 75014, France. anne.pinton@aphp.fr.

Keywords

Humans, Placenta Accreta, Postpartum Hemorrhage, Blood Transfusion, Cesarean Section, Hysterectomy, Severity of Illness Index, Cohort Studies, Pregnancy, Adult, France, Italy, Female, United Kingdom, Conservative Treatment