Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.

Original publication

DOI

10.1016/j.str.2007.02.006

Type

Journal article

Journal

Structure

Publication Date

04/2007

Volume

15

Pages

441 - 448

Keywords

Animals, Cryoelectron Microscopy, Cytokine Receptor gp130, Interleukin-11, Mice, Protein Binding, Receptors, Interleukin-11, Signal Transduction