High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline.
Beteva A., Cipriani F., Cusack S., Delageniere S., Gabadinho J., Gordon EJ., Guijarro M., Hall DR., Larsen S., Launer L., Lavault CB., Leonard GA., Mairs T., McCarthy A., McCarthy J., Meyer J., Mitchell E., Monaco S., Nurizzo D., Pernot P., Pieritz R., Ravelli RGB., Rey V., Shepard W., Spruce D., Stuart DI., Svensson O., Theveneau P., Thibault X., Turkenburg J., Walsh M., McSweeney SM.
An automatic data-collection system has been implemented and installed on seven insertion-device beamlines and a bending-magnet beamline at the ESRF (European Synchrotron Radiation Facility) as part of the SPINE (Structural Proteomics In Europe) development of an automated structure-determination pipeline. The system allows remote interaction with beamline-control systems and automatic sample mounting, alignment, characterization, data collection and processing. Reports of all actions taken are available for inspection via database modules and web services.