Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore the distinct features of PD-L2 and identify a specific evolutionary event linked to its appearance. This work provides a deeper understanding of how the immune system adapted to mammalian placental gestation and could be an important consideration in the development of new immune checkpoint therapies.

Original publication

DOI

10.1074/jbc.h120.013307

Type

Report

Publication Date

04/2020

Volume

295

Pages

4381 - 4382

Addresses

Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom Michael.dustin@kennedy.ox.ac.uk.

Keywords

Animals, Ligands, Pregnancy, Female, Programmed Cell Death 1 Ligand 2 Protein, Eutheria, B7-H1 Antigen