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Members of four cell guidance molecule families (the netrins, slits, ephrins and semaphorins) interact with their cognate cell surface receptors to guide cells during development and maintain tissue homeostasis. Integrated structure and cell-based analyses are providing insight into the mechanisms by which these signalling systems can deliver myriad outcomes that require exquisite accuracy in timing and location. Here we review recent advances in our understanding of the roles of oligomeric states, auto-inhibition, signalling assembly size and composition in cell guidance cue function.

Original publication

DOI

10.1016/j.sbi.2019.11.007

Type

Journal article

Journal

Curr Opin Struct Biol

Publication Date

17/12/2019

Volume

61

Pages

79 - 85