Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Significance Epithelial (E)-cadherin-based adherens junctions are the basis of epithelial tissue integrity in Metazoans. They are composed of E-cadherin molecules interacting with each other from apposed cells. Using artificial supported lipid bilayers functionalized with the full-length extracellular domain of E-cadherin and live cells, we show that E-cadherin junction formation involves a nucleation process mediated by active filopodia retraction and requiring reduced mobility of E-cadherin on supported lipid bilayers. These results underscore the importance of controlling physical aspects of the cellular microenvironment with synthetic materials for in vitro live cell applications. In this case, tuning the mobility of a viscous fluid display surface enabled functional reconstitution of a cadherin-mediated adhesion junction.

Original publication




Journal article


Proceedings of the National Academy of Sciences


Proceedings of the National Academy of Sciences

Publication Date





10932 - 10937