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In an analysis of a 90-kb region around the human beta-globin gene complex we have identified at least eight sites of attachment to the nuclear scaffold (SARs). While these have many potential functions, there appears to be a particular association with sequences important in the regulation of the complex. Two SARs are close to the known enhancer-like elements of the beta-globin gene. SARs flanking the complex co-habit with the boundaries of the putative beta-like globin gene regulatory domain. In contrast, we have detected no SARs within a 140-kb region of the human alpha-globin gene complex. If SARs play a role in the regulation of gene expression then this structural difference would imply a difference in the regulation of the two complexes.

Original publication

DOI

10.1002/j.1460-2075.1988.tb03205.x

Type

Journal article

Journal

The EMBO journal

Publication Date

11/1988

Volume

7

Pages

3337 - 3344

Addresses

Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

Keywords

Cell Nucleus, Humans, Globins, DNA, Blotting, Southern, Restriction Mapping, Nucleic Acid Hybridization, Gene Expression Regulation, Binding Sites, Multigene Family