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Restriction endonuclease mapping of nondeletion alpha-thalassemia determinants from a variety of racial groups showed no detectable abnormalities within a 40-kilobase region of the zeta-alpha globin gene cluster. By using a zeta-specific probe, we defined three different types of interactions that give rise to Hb H disease, each involving a nondeletion alpha-thalassemia haplotype. mRNA analysis showed further diversity within these groups, indicating that there are at least three nondeletion determinations.

Original publication

DOI

10.1073/pnas.78.9.5833

Type

Journal article

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Date

09/1981

Volume

78

Pages

5833 - 5837

Keywords

Humans, Thalassemia, Chromosome Deletion, DNA Restriction Enzymes, Hemoglobins, Abnormal, Hemoglobin H, RNA, Messenger, Chromosome Mapping, Genes, Genes, Regulator, Molecular Weight, Genetic Linkage