The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor
Cordoba S-P., Choudhuri K., Zhang H., Bridge M., Basat AB., Dustin ML., van der Merwe PA.
Key PointsThe large extracellular domains of the tyrosine phosphatases CD45 and CD148 prevent them from inhibiting T-cell receptor triggering. These domains are required for optimal segregation from the engaged T-cell receptor, supporting the kinetic-segregation model of triggering.