Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

<jats:p>Human rhinoviruses, the major cause of mild recurrent infections of the upper respiratory tract, are small icosahedral particles. Over 100 different serotypes have been identified. The majority (91 serotypes) use intercellular adhesion molecule 1 as the cell-attachment site; ten serotypes (the minor group) bind to members of the low-density lipoprotein receptor. Three different crystal forms of the minor-group human rhinovirus serotype 2 (HRV2) were obtained by the hanging-drop vapour-diffusion technique using ammonium sulfate and sodium/potassium phosphate as precipitants. Monoclinic crystals, space group <jats:italic>P</jats:italic>2<jats:sub>1</jats:sub>, diffracted at least to 2.8 Å resolution, and two complete virus particles were located in the crystal asymmetric unit. A second type of crystals had a compact cubic like morphology and diffracted beyond 2.5 Å resolution. These crystals belong to a primitive orthorhombic space group, with unit-cell parameters <jats:italic>a</jats:italic> = 309.3, <jats:italic>b</jats:italic> = 353.5, <jats:italic>c</jats:italic> = 759.6 Å, and contain one virus particle in the asymmetric unit. A third type of crystals, with a prismatic shape and belonging to space group <jats:italic>I</jats:italic>222, was also obtained under similar crystallization conditions. These latter crystals, with unit-cell parameters <jats:italic>a</jats:italic> = 308.7, <jats:italic>b</jats:italic> = 352.2, <jats:italic>c</jats:italic> = 380.5 Å, diffracted to high resolution (beyond 1.8 Å) and contained 15 protomers per asymmetric unit; this requires that three perpendicular crystal twofold axes coincide with three of the viral particle's dyad axes.</jats:p>

Original publication




Journal article


Acta Crystallographica Section D Biological Crystallography


International Union of Crystallography (IUCr)

Publication Date





1459 - 1461