Identification of the target self-antigens in reperfusion injury
Zhang M., Alicot EM., Chiu I., Li J., Verna N., Vorup-Jensen T., Kessler B., Shimaoka M., Chan R., Friend D., Mahmood U., Weissleder R., Moore FD., Carroll MC.
<jats:p>Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.</jats:p>