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Unusual nucleic acids activate innate immunity and may be present in transformed cells. Meng et al. (2021) find that cancer-associated mutations in NF2 turn this tumor suppressor into a potent antagonist of DNA- and RNA-induced innate immune signaling.

Original publication

DOI

10.1016/j.molcel.2021.10.004

Type

Journal article

Journal

Molecular cell

Publication Date

10/2021

Volume

81

Pages

4109 - 4110

Addresses

Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.