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We report the first case of lichen planus pemphigoides (LPP) secondary to ingestion of ramipril, an angiotensin-converting enzyme inhibitor. Clinical, histological and immunofluorescent findings were all consistent with a diagnosis of LPP. Linear basement membrane zone (BMZ) staining with IgG and C3 was only seen at the roof of split-skin preparations and circulating autoantibody to the BMZ was present at a titre of 1/100. Controlled immunoblotting of epidermal extracts detected the bullous pemphigoid antigens of 230 and 180 kDa.

Original publication

DOI

10.1111/j.1365-2133.1997.tb14956.x

Type

Journal article

Journal

The British journal of dermatology

Publication Date

03/1997

Volume

136

Pages

412 - 414

Addresses

St John's Institute of Dermatology, St Thomas' Hospital, London, U.K.

Keywords

Skin, Humans, Lichen Planus, Skin Diseases, Vesiculobullous, Ramipril, Collagen, Carrier Proteins, Cytoskeletal Proteins, Nerve Tissue Proteins, Non-Fibrillar Collagens, Autoantibodies, Autoantigens, Angiotensin-Converting Enzyme Inhibitors, Immunoblotting, Middle Aged, Male, Dystonin