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The haemopoietic system provides a well-characterized and accessible system for studying the mechanisms of developmental regulation and differentiation in higher eukaryotes. Our current understanding of the steps involved in the early stages of differentiation are poorly understood but a great deal is now known about the mechanisms by which globin expression is regulated in cells committed to the erythroid lineage. Many of the critical cis-acting sequences and some of the important trans-acting factors involved have been identified and current work is focusing on how these interact to produce high levels of tissue-specific and developmentally regulated expression of the human globin genes.

Original publication

DOI

10.1016/s0950-3536(05)80065-4

Type

Journal article

Journal

Bailliere's clinical haematology

Publication Date

03/1993

Volume

6

Pages

31 - 55

Addresses

Laboratory of Gene Structure and Expression, National Institute for Medical Research, London, UK.

Keywords

Chromatin, Animals, Mice, Transgenic, Humans, Mice, Globins, Transcription Factors, Gene Expression Regulation, Methylation, Growth, Mutation