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We have studied the interaction of the alpha alpha alpha/alpha alpha gene arrangement with various beta globin genotypes (AA, AS, AC, SS and SC). Whereas this interaction has no detectable clinical or haematological effects in subjects with AA, SS or SC genotypes it is associated with a significantly increased level of Hb S or Hb C in heterozygotes for these variants. These findings indicate that the additional alpha globin gene in the alpha alpha alpha gene arrangement is functional.

Type

Journal article

Journal

British journal of haematology

Publication Date

08/1984

Volume

57

Pages

671 - 678

Keywords

Humans, Anemia, Sickle Cell, Hemoglobin SC Disease, DNA Restriction Enzymes, Globins, Hemoglobin C, Hemoglobin, Sickle, Chromosome Mapping, Genotype, Heterozygote, Homozygote, Adolescent, Adult, Child, Female, Male