Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The high expression of CD1a on Langerhans cells in normal human skin suggests a central role for this lipid antigen presenting molecule in skin homeostasis and immunity. Although the lipid antigen presenting function of CD1a has been known for years, the physiological and pathological functions of the CD1a system in human skin remain incompletely understood. This review provides an overview of this active area of investigation, and discusses recent insights into the functions of CD1a, CD1a-restricted T cells, and lipid antigens in inflammatory and allergic skin disease. We include recent publications and work presented at the biennial CD1-MR1 EMBO workshop held in 2019 in Oxford, regarding lipids that increase and those that decrease T cell responses to CD1a.

Original publication

DOI

10.1016/j.molimm.2020.12.006

Type

Journal article

Journal

Molecular immunology

Publication Date

02/2021

Volume

130

Pages

14 - 19

Addresses

Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: ad2952@cumc.columbia.edu.

Keywords

Langerhans Cells, T-Lymphocytes, Skin, Humans, Skin Diseases, Antigens, CD1, Lymphocyte Activation, Antigen Presentation