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<jats:title>Abstract</jats:title> <jats:p>A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.</jats:p>

Original publication

DOI

10.1093/infdis/jiaa224

Type

Journal article

Journal

The Journal of Infectious Diseases

Publisher

Oxford University Press (OUP)

Publication Date

29/04/2020