Roman Fischer
Associate Professor and Head of Discovery Proteomics Facility
In the Discovery Proteomics Facility of the Target Discovery Institute we provide advice in experimental design, sample preparation, sample analysis with state-of-the-art LCMS workflows and data analysis to researchers from Oxford University and national and international collaborators. We routinely use label-free quantitation, SILAC, TMT, SWATH and other methodologies on diverse samples (i.e. cells, tissues, immuno precipitates et al.) and have developed sample preparation techniques to access the deep proteome form little sample amounts using instrumentation such as Orbitrap Fusion Lumos or TimsTOF Pro.
My own interests evolve around clinical proteomics and applications for the spatial characterisation of the proteome in biological structures such as tissues and tumours. In addition, I am developing methodologies for the proteome characterisation of clinical cohort samples at high-throughput.
Recent publications
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ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders
Chatzifrangkeskou M. et al, (2025), Science Advances, 11
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The developmental environment mediates adult seminal proteome allocation in maleDrosophila melanogaster
von Hellfeld R. et al, (2025)
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Correction: CD4 T cell contact drives macrophage cell cycle G0-G1 transition.
Mlcochova P. et al, (2025), Signal transduction and targeted therapy, 10
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CD4 T cell contact drives macrophage cell cycle G0-G1 transition.
Mlcochova P. et al, (2024), Signal transduction and targeted therapy, 9
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Mortality-associated plasma proteome dynamics in a prospective multicentre sepsis cohort.
Palmowski L. et al, (2024), EBioMedicine, 111