Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Ping Zhang

Senior Postdoctoral Researcher

Statistical Functional Genomics

Emerging evidence suggests that human genetic variation underlying disease susceptibility plays a critical role in drug response variability through its regulatory effect on the transcription of target gene. However, there are challenges in harnessing of susceptibility loci for target identification and therapeutic application, including limitations in (i) exposition of causal variants within susceptibility loci, (ii) understanding of the context specificity, and (iii) mechanistic insights into their influence on cellular behaviours and clinical outcomes.

My current research is focused on systematic prioritisation and characterisation of genetic variation to understand the regulation of acute immune response, endotoxin tolerance; the interplay of innate-adaptive immunity; and development of computational and experimental approaches to uncover epigenetic features, gene sets and mediators involving immune tolerance, and compounds modulating epigenetic state that have potential as novel therapeutics. The research combines multi-omics sequencing, eQTL mapping, bioinformatic and statistical analyses to study variation in disease relevant primary immune cells and human iPSC-derived models.