Isabela Pedroza-Pacheco, PhD
Career Development Fellow COI/CIO
Regulation of antibody responses in vaccination, infection, and cancer.
Dr Pedroza-Pacheco is a Career Development Fellow at the CAMS-Oxford Institute (COI) and the CRUK Oxford Cancer NDM Centre for Immuno-Oncology (CIO) in the Nuffield Department of Medicine at the University of Oxford. She obtained her bioengineering and immunology training at the Monterrey Institute of Technology (ITESM, Mexico) and University College London (UCL, UK). In 2014, she joined the Consortium for HIV/AIDS Vaccine Development (CHAVD) as a postdoctoral fellow at the University of Oxford. Dr Pedroza-Pacheco's dual expertise in engineering and immunology has enabled her to combine a systematic approach to understanding complex diseases in an integrative context. Dr Pedroza has made significant contributions in the field of HIV and vaccinology, from revealing cellular mechanisms that regulate T follicular helper and B cell responses to uncovering predictive cellular features needed in vaccination strategies to develop broad and potent neutralising antibodies called bnAbs.
By applying novel technologies and developing methodologies that comprehensively assess genetic and protein variations that shape cellular function, the overarching goal of Dr Pedroza’s laboratory is to improve our understanding of cellular and molecular mechanisms underlying the regulation of germinal centre responses in vaccination, infection, and cancer, to dissect mechanistic targets that could be used to improve vaccines and therapeutic strategies.