Postdoctoral research scientist and Bioinformatician
Contact information
Research groups
Elie Antoun
Senior Bioinformatician
Post-doctoral research scientist and BIoinformatician
My research focus in on the use of multimodal next generation sequencing technologies (e.g. RNAseq, ATACseq, Proteomics) to understand the complexities involved in T cell function and regulation during viral infection and in cancer settings. Currently, I am looking into:
- The function and regulation of cytotoxic CD4+ T cells, and epigenetics mechanisms that may regulate T cells function.
- Using TCR repertoire sequencing and machine learning algorithms to understand TCR clonality and specificity.
As both a wet lab scientist and a bioinformatician, I can efficiently link the biology with the bioinformatic analysis to gain a deeper understanding into T cell function and heterogeneity
Recent publications
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SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8+ T cell responses
Journal article
Wellington D. et al, (2023), Heliyon, e20076 - e20076
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Vaccine-induced CD8+ T cells are key to protection from SARS-CoV-2.
Journal article
Antoun E. et al, (2023), Nature immunology
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Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle.
Journal article
Burton MA. et al, (2023), Journal of cachexia, sarcopenia and muscle
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Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function
Journal article
Titcombe P. et al, (2022), Epigenetics, 17, 653 - 664
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DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake
Journal article
Antoun E. et al, (2022), Epigenetics, 17, 405 - 421