Postdoctoral research scientist and Bioinformatician
Contact information
Research groups
Elie Antoun
Senior Bioinformatician
Post-doctoral research scientist and BIoinformatician
My research focus in on the use of multimodal next generation sequencing technologies (e.g. RNAseq, ATACseq, Proteomics) to understand the complexities involved in T cell function and regulation during viral infection and in cancer settings. Currently, I am looking into:
- The function and regulation of cytotoxic CD4+ T cells, and epigenetics mechanisms that may regulate T cells function.
- Using TCR repertoire sequencing and machine learning algorithms to understand TCR clonality and specificity.
As both a wet lab scientist and a bioinformatician, I can efficiently link the biology with the bioinformatic analysis to gain a deeper understanding into T cell function and heterogeneity
Recent publications
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Hamid MHBA. et al, (2024), Nature Immunology, 25, 834 - 846
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The serum small non‐coding RNA (SncRNA) landscape as a molecular biomarker of age associated muscle dysregulation and insulin resistance in older adults
Burton MA. et al, (2024), The FASEB Journal, 38
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DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults.
Burton MA. et al, (2023), Skeletal muscle, 13
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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey A. et al, (2023), Nature communications, 14
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SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8+ T cell responses
Wellington D. et al, (2023), Heliyon, 9, e20076 - e20076