Postdoctoral research scientist and Bioinformatician
Post-doctoral research scientist and BIoinformatician
My research focus in on the use of multimodal next generation sequencing technologies (e.g. RNAseq, ATACseq, Proteomics) to understand the complexities involved in T cell function and regulation during viral infection and in cancer settings. Currently, I am looking into:
- The function and regulation of cytotoxic CD4+ T cells, and epigenetics mechanisms that may regulate T cells function.
- Using TCR repertoire sequencing and machine learning algorithms to understand TCR clonality and specificity.
As both a wet lab scientist and a bioinformatician, I can efficiently link the biology with the bioinformatic analysis to gain a deeper understanding into T cell function and heterogeneity
DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults.
Burton MA. et al, (2023), Skeletal muscle, 13
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey A. et al, (2023), Nature communications, 14
SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8+ T cell responses
Wellington D. et al, (2023), Heliyon, e20076 - e20076
Vaccine-induced CD8+ T cells are key to protection from SARS-CoV-2.
Antoun E. et al, (2023), Nature immunology
Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle.
Burton MA. et al, (2023), Journal of cachexia, sarcopenia and muscle