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Catherine Wong


  • Peking Union Medical College Hospital (PUMCH)


I obtained my PhD from the University of Hong Kong in 2003, majoring in Fundamental Mass Spectrometry (Physical Chemistry). Possessing both physical and analytical techniques I thus have solid foundations for interdisciplinary researches. I studied proteomics for 8 years since 2005 in John Yate’s lab. Since then, I have employed this technology to make considerable contributions.

Research Interests

My research interests lie mainly on development of cutting-edge mass spectrometry-based proteomic technologies, including Single Cell Proteomics (SCP), 4D-DIA high-throughput technology based on Trapped Ion Mobility-TOF MS, novel methods on protein glycosylation identifications, and new protein database search algorithms. I also work on the translational proteomics to discover authentic disease biomarkers and to unveil disease mechanisms based on well-designed large clinical cohort.

Key Publications

Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution.

Yujiao Dang, Liu Zhu, Peng Yuan, Qiang Liu, Qianying Guo, Xi Chen, Shuaixin Gao, Xiao Liu, Shushen Ji, Yifeng Yuan, Ying Lian, Rong Li, Liying Yan, Catherine CL Wong, Jie Qiao. Cell Discovery, 2023.

O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule.

Wenmin Tian, Delin Li, Nan Zhang, Guijie Bai, Kai Yuan, Haixia Xiao, Feng Gao, Yang Chen, Catherine CL Wong, George Fu Gao.  Cell Research, 2021.

Global Profiling of RNA-Binding Protein Target Sites in Single Cells by LACE-seq.

Ruibao Su, Li-hua Fan, Changchang Cao, Lei Wang, Zongchang Du, Zhaokui Cai, Ying-Chun Ouyang, Yue Wang, Qian Zhou, Ligang Wu, Nan Zhang, Xiaoxiao Zhu, Wen-long Lei, Hailian Zhao, Yong Tian, Shunmin He, Catherine CL Wong, Qing-Yuan Sun, Yuanchao Xue. Nature Cell Biology, 2021.

Immune suppression in the early stage of COVID-19 disease. 

Wenmin Tian, Nan Zhang, Ronghua Jin, Yingmei Feng, Siyuan Wang, Shuaixin Gao, Ruqin Gao, Guizhen Wu, Wenjie Tan*, Yang Chen, George, Fu Gao, and Catherine CL Wong. Nature Communications, 2020. 

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy.

Wei Wu, Qiuping Zhou, Takeya Masubuchi, Xiaoshan Shi, Hua Li, Min Huang, Hengyu Zhu, Xinyi Xu, Xing He, Haopeng Wang, Enfu Hui, Catherine CL Wong and Chenqi Xu.  Cell, 2020.